[Effects of neuraxial block and general anesthesia on tumor metastasis in rats].
Nan Fang Yi Ke Da Xue Xue Bao
; 28(12): 2218-20, 2008 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-19114362
ABSTRACT
OBJECTIVE:
To investigate the effects of different anesthesia methods on immune surveillance and tumor metastasis in tumor-bearing rats.METHODS:
Seventy-two Fischer 344 rats were randomly assigned into 3 equal groups and anesthetized for 1 h with ketamine (group K), propofol (group P), or neuraxial block (group B). All the rats were subjected to laparotomy followed by intravenous injection of MADB106 tumor cells, and 24 h after the injection, the number and activity of circulating CD3(+), CD4(+), CD8(+), and D4(+)/CD8(+) lymphocyte subsets and NK cellèCD161a(+)éwere assessed. Three weeks later, the lung metastases were counted.RESULTS:
Compared with those in group B, the numbers of CD3(+), CD4(+), CD8(+), and CD161a(+) lymphocytes and the activity of circulating NK cells were significantly reduced, and the lung metastases of MADB106 increased significantly in groups K and P (P<0.05 or 0.01 ). The activity of immune surveillance in group K was significantly lower than that in group P except for CD8(+) cells, and the tumor metastases in group K increased significantly in comparison with those in group P (P<0.05 or 0.01).CONCLUSION:
Neuraxial block provides protection of the activity of immune surveillance and reduces tumor metastases in tumor-bearing rats compared with general anesthesia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Anestesia Epidural
/
Anestesia General
/
Neoplasias Pulmonares
/
Metástasis de la Neoplasia
/
Bloqueo Nervioso
Límite:
Animals
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2008
Tipo del documento:
Article
País de afiliación:
China