Generation of DNA interstrand cross-links by post-synthetic reductive amination.
Org Lett
; 11(3): 661-4, 2009 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-19132933
ABSTRACT
DNA interstrand cross-links (ICLs) are the clinically most relevant adducts formed by many antitumor agents. To facilitate the study of biological responses triggered by ICLs, we developed a new approach toward the synthesis of mimics of nitrogen mustard ICLs. 7-Deazaguanine residues bearing acetaldehyde groups were incorporated into complementary strands of DNA and cross-link formation induced by double reductive amination. Our strategy enables the synthesis of major groove cross-links in high yields and purity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligonucleótidos
/
ADN
/
Modelos Moleculares
/
Reactivos de Enlaces Cruzados
/
Antineoplásicos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Suiza