Peripheral delivery of a ROCK inhibitor improves learning and working memory.
Behav Neurosci
; 123(1): 218-23, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19170447
ABSTRACT
Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aprendizaje por Laberinto
/
1-(5-Isoquinolinesulfonil)-2-Metilpiperazina
/
Proteína de Unión al GTP rhoA
/
Memoria a Corto Plazo
Límite:
Animals
Idioma:
En
Revista:
Behav Neurosci
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos