Neural correlates of episodic and semantic memory retrieval in borderline personality disorder: an fMRI study.
Psychiatry Res
; 171(2): 94-105, 2009 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-19176280
Verbal memory impairment in borderline personality disorder (BPD) is still a matter of debate. In this study we combine investigations of both, memory retrieval as well as underlying neural circuits in BPD. Functional magnetic resonance imaging (fMRI) was used to study regional brain activation in 18 right-handed female patients with BPD and 18 matched controls during the retrieval of an episodic memory retrieval (EMR) task (free recall of a word list) and a semantic memory retrieval (SMR) task (verbal fluency). Despite unaffected performance in EMR and SMR, patients with BPD showed task-specific increased activation compared with controls. During EMR, the increased activation encompassed the posterior cingulate cortex bilaterally, the left middle and superior temporal gyrus, the right inferior frontal gyrus, and the right angular gyrus. SMR was associated with increased activation of the posterior cingulate cortex, of the right fusiform gyrus, of the left anterior cingulate cortex, and of the left postcentral gyrus. Our findings suggest that BPD patients may need to engage larger brain areas to reach a level of performance in episodic and semantic retrieval tasks that is comparable to that of healthy controls.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recuerdo Mental
/
Semántica
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Aprendizaje Verbal
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Trastorno de Personalidad Limítrofe
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Procesamiento de Imagen Asistido por Computador
/
Encéfalo
/
Imagen por Resonancia Magnética
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Psychiatry Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Irlanda