Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients.
Eur J Gastroenterol Hepatol
; 21(9): 969-72, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19194305
ABSTRACT
OBJECTIVES:
The effect of light-to-moderate alcohol consumption (LMAC) in nonalcoholic fatty liver disease (NAFLD) remains a controversial subject. The aim of this study was to evaluate the relationship between LMAC and the severity of NAFLD in morbidly obese patients.METHODS:
We studied 132 patients undergoing liver biopsy during bariatric surgery. The patients were divided into three groups G1 alcohol intake greater than 20 g/day and less than 40 g/day; G2 alcohol intake less than 20 g/day; G3 no alcohol intake. Insulin resistance was defined by the Homeostasis Model Assessment (>3). NAFLD was classified according to the Matteoni types type I steatosis alone; type II steatosis with inflammation; types III-IV steatosis with ballooning and/or fibrosis.RESULTS:
The mean age was 37.3+/-11 years. Sixty-three percent were females and body mass index was 43.9+/-5.6 kg/m. G1, G2, and G3 included 19, 56, and 57 patients, respectively. Histological diagnoses classified by levels of alcohol were G1 10.5% normal liver, 89.5% type III or IV; G2 10.7% normal liver, 1.8% type I or II, and 87.5% grade III or IV; G3 10.5% normal liver, 3.5% type I or II, and 86% type III or IV (one had cirrhosis). The presence of IR was similar in moderate and no alcohol consumption (81.3 and 78.7%) but significantly less in the light consumption group (54%, P<0.05).CONCLUSION:
The results suggest that LMAC may have a protection effect against IR in severely obese patients. However, it had no impact on the severity of activity and stage of liver disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Obesidad Mórbida
/
Consumo de Bebidas Alcohólicas
/
Hígado Graso
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Gastroenterol Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil