Marine macrolides, a promising source of antitumor compounds.
Anticancer Agents Med Chem
; 9(2): 122-37, 2009 Feb.
Article
en En
| MEDLINE
| ID: mdl-19199861
ABSTRACT
Marine organisms have attracted scientific community as a rich source of natural products with unusual structural features and remarkable biological activities. Marine macrolides are a prominent class of natural products characterized by a highly oxygenated polyene backbone containing a macrocyclic lactone as a conformational constraint. Many marine macrolides possess outstanding cell growth antiproliferative properties, making them valuable molecular probes for the investigation of biochemical pathways and promising lead compounds for the development of new antitumor chemotherapeutic agents. In the present review we intend to focus on marine macrolides with potent cytotoxic activity that could be exploited in cancer research and therapy, along with those macrolides currently in clinical trials and/or preclinical development.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Macrólidos
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Anticancer Agents Med Chem
Asunto de la revista:
ANTINEOPLASICOS
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
España