S100beta protein expression: gender- and age-related daily changes.
Neurochem Res
; 34(8): 1355-62, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19205880
ABSTRACT
S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-term potentiation in adult brains. The ability of S100beta to rapidly regulate neuronal morphology raises the interesting point of whether there are daily rhythm or gender differences in S100beta level in the brain. To answer this question, the S100beta expression in adult female and male rats, as well as in adult female CD-21 and S100beta -/- female mice, were investigated. Scintillation counting and morphometric analysis of the immunoreactivity of S100beta, showed rhythmic daily expression. The female and male rats showed opposite cycles. Females presented the highest value at the beginning of the rest phase (500 h), while in males the maximum value appeared in the beginning of the motor activity period (2100 h). These results confirm previous S100beta evaluations in human serum and cerebrospinal fluid reporting the protein's function as a biomarker for brain damage (Gazzolo et al. in Clin Chem 49967-970, 2003; Clin Chim Acta 330131-133, 2003; Pediatr Res 581170-1174, 2005), similar behavior was also observed for GFAP in relation to Alzheimer Disease (Fukuyama et al. in Eur Neurol 4635-38, 2001). The data should be taken into account when considering S100beta as a biomarker of health condition. In addition, the results raise questions on which structure or condition imposes these rhythms as well as on the physiological meaning of the observed gender differences.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
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Proteínas S100
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Factores de Crecimiento Nervioso
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurochem Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos