White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging.
Brain Res
; 1265: 171-7, 2009 Apr 10.
Article
en En
| MEDLINE
| ID: mdl-19233148
ABSTRACT
This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group. The HFA group also had decreased FA in the frontal lobe and left temporal lobe. By combining DT-MRI FA and MRI volumetric analyses based on the VBM model, the results showed consistent white matter abnormalities in a group of Chinese children with HFA.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lóbulo Parietal
/
Trastorno Autístico
/
Imagen de Difusión por Resonancia Magnética
/
Lóbulo Frontal
/
Giro del Cíngulo
Tipo de estudio:
Observational_studies
Límite:
Child
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Brain Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
China