Histological diagnosis of sickle cell trait: a blinded analysis.
Am J Forensic Med Pathol
; 30(1): 36-9, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19237851
ABSTRACT
Hemoglobin electrophoresis is the method most commonly used to diagnose sickle cell trait (SCT) at autopsy. However, in some cases, this accepted technique is unable to be used due to either insufficient sampling, sample degradation, or lack of forethought; histology samples and/or gross tissue are not subject to these sampling errors and are routinely taken during autopsies. In this study, we attempted to determine whether one can reliably diagnose SCT using histology only. Histology sections of commonly sampled tissues (primarily heart, lung, and liver) from 9 decedents with SCT, 3 decedents with hemoglobin SC disease, and 18 control cases were examined in a blinded fashion as single slides and then as slide sets. When evaluating slide sets, the reviewers were able to identify the cases with SCT (sensitivity = 95%, specificity = 100%). Such samples could be used to diagnose SCT even decades after the original death certification and long after samples necessary for other techniques have degraded or been discarded.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rasgo Drepanocítico
/
Patologia Forense
/
Eritrocitos Anormales
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Forensic Med Pathol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos