Rigidity-dependent cross talk between integrin and cadherin signaling.
Biophys J
; 96(6): L39-41, 2009 Mar 18.
Article
en En
| MEDLINE
| ID: mdl-19289031
ABSTRACT
Integrin-cadherin cross talk is an important aspect of cell function. We explored this signaling using substrates micropatterned with islands of fibronectin surrounded by E-cadherin, capturing the segregation of these signals in normal tissue. While MDCK cells were able to concurrently form adhesive structures with these two proteins, engagement of fibronectin by MCF-7 cells, an adenocarcinoma cell line, inhibited response of these cells to E-cadherin. We further demonstrated that this inhibition is rigidity dependent; on soft elastomer substrates with Young's modulus in the range of tens of kiloPascals, MCF-7 cells were able to engage both integrin and cadherin ligands.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Cadherinas
/
Integrinas
/
Elasticidad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biophys J
Año:
2009
Tipo del documento:
Article