The expression and prognostic significance of Cks1 in salivary cancer.
Cancer Invest
; 27(5): 512-20, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19296297
ABSTRACT
Cks1 is an essential factor in facilitating Skp2-dependent degradation of p27, but its role in salivary malignancies is unknown. Expression of cyclin-dependent kinase subunit 1 (Cks1) was examined in 64 salivary malignancies, compared with p27, S-phase kinase protein 2 (Skp2), Ki-67, p53, and TDT-mediated dutp-biotin nick end labeling (TUNEL) expression, and with THE patient's clinical and pathological parameters. Cks1 expression was markedly increased in 30 patients (47%) and strongly correlated with increased expression of Skp2, Ki-67, p53, and TUNEL, but inversely with p27 levels. High expression of Cks1 WAS strongly associated with lymph node metastases and poor prognosis and survival. Cks1 alterations may have a significant biological role in the pathogenesis of salivary cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de las Glándulas Salivales
/
Proteínas Portadoras
/
Quinasas Ciclina-Dependientes
Tipo de estudio:
Prognostic_studies
Límite:
Aged80
Idioma:
En
Revista:
Cancer Invest
Año:
2009
Tipo del documento:
Article
País de afiliación:
Israel