Antimalarial sesquiterpene lactones from Distephanus angulifolius.
Phytochemistry
; 70(5): 601-7, 2009 Mar.
Article
en En
| MEDLINE
| ID: mdl-19298984
ABSTRACT
Combined use of bioassay-guided fractionation based on in vitro antiplasmodial assay and dereplication based on HPLC-PDA-MS-SPE-NMR led to isolation of (6S,7R,8S)-14-acetoxy-8-[2-hydroxymethylacrylat]-15-helianga-1(10),4,11(13)-trien-15-al-6,12-olid and (5R,6R,7R,8S,10S)-14-acetoxy-8-[2-hydroxymethylacrylat]-elema-1,3,11(13)-trien-15-al-6,12-olid, along with vernodalol, vernodalin, and 11,13beta-dihydroxyvernodalin from extract of Distephanus angulifolius. All compounds were identified by spectroscopic methods, including 1D and 2D homo- and heteronuclear NMR experiments. The isolated compounds showed IC(50) values in the range 1.6-3.8 microM and 2.1-4.9 microM against chloroquine sensitive D10 and chloroquine resistant W2 Plasmodium falciparum strains, respectively.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Sesquiterpenos
/
Vernonia
/
Lactonas
/
Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Phytochemistry
Año:
2009
Tipo del documento:
Article
País de afiliación:
Dinamarca