The TRH stimulation test in Alzheimer's disease and major depression: relationship to clinical and CSF measures.
Biol Psychiatry
; 30(6): 567-76, 1991 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-1932406
ABSTRACT
A blunted thyroid-stimulating hormone (TSH) response to exogenous thyrotropin-releasing hormone (TRH) has been reported to occur consistently in patients with major depression and less consistently in patients with Alzheimer's disease (AD). In this study we compared the TSH response to TRH in a large group (n = 40) of AD patients, elderly patients with major depression (n = 17), and age-matched controls (n = 14) to further characterize how it may relate to clinical variables, baseline thyroid function tests, and cerebrospinal fluid measures. Comparisons of TRH stimulation test response across all three groups revealed that patients with major depression had lower stimulated TSH levels (delta maxTSH) (p less than 0.02) and higher (though still within normal limits) mean thyroxine (T4) levels (p less than 0.05) than the AD patients or controls. AD patients with a blunted TSH response had a significantly higher mean free T4 (FT4) level (p less than 0.03) and tended to be more severely demented (p less than 0.01) than those with a nonblunted response.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Tirotropina
/
Hormona Liberadora de Tirotropina
/
Trastorno Depresivo
/
Enfermedad de Alzheimer
/
Metoxihidroxifenilglicol
Tipo de estudio:
Diagnostic_studies
Aspecto:
Patient_preference
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Año:
1991
Tipo del documento:
Article