Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs.
Biochem Biophys Res Commun
; 381(2): 198-203, 2009 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-19338773
AIMS: Oxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling. METHODS: Twenty dogs were randomly divided into sham-operated, control, and probucol-treated groups. We identified apoptosis and histopathological changes in the atria. Oxidative stress was measured by lipid peroxidation and echocardiographic examinations were performed. RESULTS: Atrial apoptosis indexes were dramatically decreased in the probucol-treated group compared to the control group. Relative to the control group, the percentage of myolysis was dramatically decreased in the probucol-treated group (p < 0.01). There was less lipid peroxidation in the probucol-treated group than the control group. Atrial function was dramatically elevated in the probucol-treated group. CONCLUSIONS: The results of this study indicate that the antioxidant probucol suppresses atrial structural remodeling and may act as a new therapy for AF.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Probucol
/
Fibrilación Atrial
/
Apoptosis
/
Atrios Cardíacos
/
Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2009
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos