Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test.
Cancer Res
; 37(7 Pt 1): 2209-13, 1977 Jul.
Article
en En
| MEDLINE
| ID: mdl-193638
Seventeen cancer chemotherapeutic agents were tested for their ability to mutate Salmonella typhimurium tester strains in the Salmonella/microsome mutagenicity test. There was a high correlation between the mutagenicity and carcinogenicity of a given agent. Carcinogens positive in the test were Adriamycin, daunomycin, 1-propanol-3,3'-iminodimethanesulfonate, cyclophosphamide, isophosphamide, hycanthone, chlornaphazin, nitrogen mustard, uracil mustard, melphalan, and thio-tepa. Two carcinogesn, actinomycin D and bleomycin, were not detected as mutagens. The presumptive noncarcinogen, methotrexate, was negative in the test. Tilorone and 6-mercaptopurine, tentatively classified as noncarcinogens, were mutagenic. The carcinogenicity of cis-dichlorodiammineplatinum(II), which was positive in the test, has not been determined.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Salmonella typhimurium
/
Mutágenos
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Cancer Res
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos