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Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Pérez, Itxaro; Varona, Adolfo; Blanco, Lorena; Gil, Javier; Santaolalla, Francisco; Zabala, Aitor; Ibarguen, Agustin Martínez; Irazusta, Jon; Larrinaga, Gorka.
Afiliación
  • Pérez I; Department of Physiology, School of Medicine and Dentistry, University of the Basque Country, Bilbao, Spain.
Head Neck ; 31(10): 1335-40, 2009 Oct.
Article en En | MEDLINE | ID: mdl-19373777
ABSTRACT

BACKGROUND:

Involvement of peptidases in carcinogenic processes of several tumor types has been investigated in recent years. Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide and accounts for more than 90% of all head and neck cancers. Increased understanding of its pathophysiology has led to implication of several proteinases, specially matrix metalloproteinases, in its genesis, growth, and dissemination. However, very little is known about involvement of peptidases in this neoplasm.

METHODS:

Seventeen HNSCC tissue samples were selected for the study. Tumor and normal tissue samples were frozen for enzymatic study. The catalytic activity for a pool of peptidases (PSA, APN/CD13, APB, APA, Asp-AP, CAP, DPPIV/CD26, NEP/CD10, and PGI) was measured fluorometrically.

RESULTS:

The activity of 2 cell surface aminopeptidases (APN/CD13 and APA) and a cytosolic aminopeptidase (Asp-AP) was significantly increased in HNSCC tissues.

CONCLUSIONS:

These data show the involvement of cell surface and cytosolic peptidases in the mechanisms underlying HNSCC.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Antígenos CD13 / Glutamil Aminopeptidasa / Neoplasias de Cabeza y Cuello Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2009 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Antígenos CD13 / Glutamil Aminopeptidasa / Neoplasias de Cabeza y Cuello Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2009 Tipo del documento: Article País de afiliación: España