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Expression of EGR-1 in a subset of olfactory bulb dopaminergic cells.
Akiba, Nami; Jo, Sunna; Akiba, Yosuke; Baker, Harriet; Cave, John W.
Afiliación
  • Akiba N; Department of Neurology and Neuroscience, Burke Medical Research Institute, Weill Cornell Medical College, 785 Mamaroneck Ave., White Plains, NY 10605, USA.
J Mol Histol ; 40(2): 151-5, 2009 Apr.
Article en En | MEDLINE | ID: mdl-19387849
In the adrenal medulla, binding of the immediate early gene (IEG) proteins, EGR-1 (ZIF-268/KROX-24/NGFI-A) and AP-1, to the tyrosine hydroxylase (Th) proximal promoter mediate inducible Th expression. The current study investigated the potential role of EGR-1 in inducible Th expression in the olfactory bulb (OB) since IEGs bound to the AP-1 site in the Th proximal promoter are also necessary for activity-dependent OB TH expression. Immunohistochemical analysis of a naris-occluded mouse model of odor deprivation revealed weak EGR-1 expression levels in the OB glomerular layer that were activity-dependent. Immunofluorescence analysis indicated that a majority of glomerular cells expressing EGR-1 also co-expressed TH, but only small subset of TH-expressing cells contained EGR-1. By contrast, granule cells, which lack TH, exhibited EGR-1 expression levels that were unchanged by naris closure. Together, these finding suggest that EGR-1 mediates activity-dependent TH expression in a subset of OB dopaminergic neurons, and that there is differential regulation of EGR-1 in periglomerular and granule cells.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Dopamina / Regulación de la Expresión Génica / Proteína 1 de la Respuesta de Crecimiento Precoz / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Mol Histol Asunto de la revista: HISTOCITOQUIMICA Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Dopamina / Regulación de la Expresión Génica / Proteína 1 de la Respuesta de Crecimiento Precoz / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Mol Histol Asunto de la revista: HISTOCITOQUIMICA Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos