Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats.
J Comp Physiol B
; 161(3): 319-22, 1991.
Article
en En
| MEDLINE
| ID: mdl-1939742
ABSTRACT
Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of controls, while that of the obese rats was 14% higher than in control animals. The resting metabolic rate for Kwashiorkor animals was 50% of the predicted basal metabolic rate (BMR), whereas that of the obese rats was 23% higher than the predicted BMR. The mitochondrial oxygen consumption patterns, using malate plus glutamate or succinate as respiratory substrates, revealed that the resting respiration (state 4) was 23.9% higher in Kwashiorkor and 29.1% higher in obese animals, while the active (state 3) respiration was 34.8% lower in Kwashiorkor and 43.3% lower in obese rats compared to controls. The respiratory control ratios (RCR) were 51.1% and 43.8% in Kwashiorkor and obese rats, respectively, relative to the values in control rats. It is concluded from these studies that Kwashiorkor disease and diet-induced obesity appear to interfere with oxygen utilization at the level of state 3 mitochondrial respiration, which is markedly decreased when compared to the values for control animals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metabolismo Basal
/
Kwashiorkor
/
Mitocondrias
/
Obesidad
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Comp Physiol B
Asunto de la revista:
BIOQUIMICA
/
FISIOLOGIA
/
METABOLISMO
Año:
1991
Tipo del documento:
Article
País de afiliación:
Nigeria