Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds.
Chem Pharm Bull (Tokyo)
; 57(5): 476-80, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19420778
ABSTRACT
trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN Polimerasa beta
/
Ácidos Cumáricos
/
ADN Polimerasa I
/
Inhibidores Enzimáticos
/
Ésteres
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP