Operationally simple copper-promoted coupling of terminal alkynes with benzyl halides.
J Org Chem
; 74(10): 3997-4000, 2009 May 15.
Article
en En
| MEDLINE
| ID: mdl-19422268
ABSTRACT
Benzyl chlorides and bromides are shown to undergo copper-promoted coupling with a variety of terminal alkynes including, for the first time, electron-poor acetylenes such as methyl propiolate. The reaction permits easy access to a wide range of (functionalized) benzyl-substituted propiolates (as well as several related alkynes) from commercially available benzyl halides. These products should in turn function as useful building blocks for the synthesis of previously inaccessible (functionalized) benzyl-substituted heterocycles.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Bencilo
/
Cobre
/
Alquinos
/
Halógenos
Idioma:
En
Revista:
J Org Chem
Año:
2009
Tipo del documento:
Article