Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism.
Hippocampus
; 19(10): 973-80, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19437410
ABSTRACT
Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spatial) and object substitution (nonspatial) learning. These behavioral changes were accompanied by increased expression of BDNF protein in the dentate gyrus, hippocampus, and perirhinal cortex. The effects of exercise on object substitution were mimicked by intracerebroventricular injection of BDNF protein. These data are consistent with the hypothesis that exercise has the potential to enhance cognitive function in young healthy rats, possibly via a mechanism involving increased BDNF expression in specific brain regions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
/
Carrera
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Percepción Espacial
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Factor Neurotrófico Derivado del Encéfalo
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Hipocampo
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Aprendizaje
Límite:
Animals
Idioma:
En
Revista:
Hippocampus
Asunto de la revista:
CEREBRO
Año:
2009
Tipo del documento:
Article
País de afiliación:
Irlanda