Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding.
Prion
; 3(2): 78-83, 2009.
Article
en En
| MEDLINE
| ID: mdl-19458490
ABSTRACT
Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal death remain unclear, a commonly used antibiotic, minocycline, has been shown to reduce the progression and severity of disease in several models of neurodegeneration by variously downregulating these molecular pathways. Here we discuss the evidence for the potential of minocycline as a broad-specificity therapeutic agent for those neurodegenerative diseases that are characterized by the presence of misfolded proteins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Minociclina
/
Antibacterianos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Prion
Asunto de la revista:
BIOQUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido