Effects of pomegranate juice and extract polyphenols on platelet function.
J Med Food
; 12(2): 334-9, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-19459734
ABSTRACT
Several studies have shown that polyphenols reduce cardiovascular accidents in high-risk patients; in particular, the inhibition of platelet function may be responsible for part of this benefit. This research studied the antiplatelet effect of Wonderful variety pomegranate (Punica granatum) products, which contain primarily hydrolyzed tannins such as ellagitannins. We have investigated in vitro the effects of treatment with either pomegranate juice (PJ) or the polyphenol-rich extract from pomegranate fruit (POMx) on platelet aggregation, calcium mobilization, thromboxane A(2) production, and hydrogen peroxide formation, induced by collagen and arachidonic acid. PJ and POMx reduce all the platelet responses studied. POMx showed a stronger action in reducing platelet activation; moreover, POMx is active at the concentration that it is possible to obtain after polyphenol-rich food intake (2 microM). These results demonstrated that the cardiovascular health benefits of pomegranate may in part be related to the ability of polyphenols to inhibit platelet function. In fact, PJ and pomegranate extract have similar effects at concentrations expected for normal intake.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenoles
/
Flavonoides
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Plaquetas
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Inhibidores de Agregación Plaquetaria
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Extractos Vegetales
/
Agregación Plaquetaria
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Lythraceae
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Preparaciones de Plantas
Idioma:
En
Revista:
J Med Food
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
MEDICINA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia