Combination of BCG and interferon intravesical immunotherapy: an update.
World J Urol
; 27(3): 343-6, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19479263
OBJECTIVE: To provide an update on the use of interferon (IFN) in the treatment of non-muscle invasive bladder cancer (NMIBC). METHODS: A literature review of intravesical IFN was performed. RESULTS: In vitro evidence suggested that IFN combined with BCG may have a synergistic effect on the immune response, and treatment regimens with IFN have used reduced BCG dosage in an attempt to reduce toxicity. IFN combined with BCG may salvage some patients, single-course BCG failures or late relapsers, while those that relapse quickly may be destined to failure. However, based on the results of a recently reported randomized trial, the addition of IFN may not improve efficacy in BCG naïve patients. CONCLUSIONS: BCG plus IFN remains an alternative in selected patients with NMIBC who fail intravesical BCG.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacuna BCG
/
Adyuvantes Inmunológicos
/
Interferones
/
Antineoplásicos
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
World J Urol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania