Single-molecule mechanical unfolding of amyloidogenic beta2-microglobulin: the force-spectroscopy approach.
Chemphyschem
; 10(9-10): 1471-7, 2009 Jul 13.
Article
en En
| MEDLINE
| ID: mdl-19496082
ABSTRACT
The recombinant production of a novel chimeric polyprotein is described. The new protein contains either wild-type beta(2)-microglobulin (beta(2)m) or its truncated variant (DeltaN6 beta(2)m) (see picture). Structural characterization is achieved by means of single-molecule force spectroscopy studies of specific beta(2)m regions which could be involved in amyloidogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microglobulina beta-2
Idioma:
En
Revista:
Chemphyschem
Asunto de la revista:
BIOFISICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia