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Association of tumor necrosis factor-alpha with fever and pulmonary lesion score in pigs experimentally infected with swine influenza virus subtype H1N2.
Kim, Bongtae; Ahn, Kyoung Kyu; Ha, Yooncheol; Lee, Yong Hoon; Kim, Duyeol; Lim, Jeong Han; Kim, Sung-Hoon; Kim, Mi-Young; Cho, Kyung-Dong; Lee, Bog-Hieu; Chae, Chanhee.
Afiliación
  • Kim B; Department of Veterinary Pathology, Seoul National University, Seoul, Republic of Korea.
J Vet Med Sci ; 71(5): 611-6, 2009 May.
Article en En | MEDLINE | ID: mdl-19498287
ABSTRACT
The relationship between tumor necrosis factor (TNF)-alpha level, body temperature, and pulmonary lesion score was determined in 3-week-old pigs inoculated intranasally with swine influenza virus (SIV) subtype H1N2. The expression of TNF-alpha was measured in bronchoalveolar lavage (BAL) fluids by enzyme-linked immunosorbent assay and lung tissues by immunohistochemistry. In BAL fluid, TNF-alpha concentration was maximal at 1 days post-inoculation (dpi), declined markedly by 3 dpi (P<0.05) and steady thereafter. Mean rectal temperatures were above 40 degrees C for the infected groups at 1 dpi and declined markedly by 3 dpi. The body temperatures were correlated with the levels of TNF-alpha in BAL fluids from pigs experimentally infected with SIV (r(s)=0.9754, P<0.05). The pulmonary lesion scores were correlated with the means of positive cells by immunohistochemistry for TNF- alpha (r(s)=0.9949, P<0.001). The results suggest that the expression of TNF-alpha protein plays an important role in induction of pulmonary lesion and clinical sign such as fever in SIV infection.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Porcinos / Factor de Necrosis Tumoral alfa / Infecciones por Orthomyxoviridae / Subtipo H1N1 del Virus de la Influenza A / Enfermedades Pulmonares Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Vet Med Sci Asunto de la revista: MEDICINA VETERINARIA Año: 2009 Tipo del documento: Article
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Porcinos / Factor de Necrosis Tumoral alfa / Infecciones por Orthomyxoviridae / Subtipo H1N1 del Virus de la Influenza A / Enfermedades Pulmonares Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Vet Med Sci Asunto de la revista: MEDICINA VETERINARIA Año: 2009 Tipo del documento: Article