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Liquid-phase synthesis of block copolymers containing sequence-ordered segments.
Pfeifer, Sebastian; Zarafshani, Zoya; Badi, Nezha; Lutz, Jean-François.
Afiliación
  • Pfeifer S; Nanotechnology for Life Science Research Group, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam-Golm 14476, Germany.
J Am Chem Soc ; 131(26): 9195-7, 2009 Jul 08.
Article en En | MEDLINE | ID: mdl-19522508
Monodisperse sequence-defined oligomers have been synthesized in solution in the absence of protecting groups. These structures have been prepared stepwise using two consecutive chemoselective reactions: 1,3-dipolar cycloaddition of terminal alkynes and azides and amidification of carboxylic acids with primary amines. These oligomers were efficiently constructed on either a conventional solid support (commercial Wang resin) or tailor-made soluble polystyrene supports synthesized by atom-transfer radical polymerization. The latter approach was found to be very versatile. Indeed, well-defined soluble macromolecular supports allowed not only the synthesis and cleavage of defined oligomers (i.e., sacrificial support) but also the preparation of noncleavable block copolymers containing sequence-defined segments.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Azidas / Ácidos Carboxílicos / Alquinos / Aminas Idioma: En Revista: J Am Chem Soc Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Azidas / Ácidos Carboxílicos / Alquinos / Aminas Idioma: En Revista: J Am Chem Soc Año: 2009 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos