On the calculation of puckering free energy surfaces.
J Chem Phys
; 130(22): 225102, 2009 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-19530791
ABSTRACT
Cremer-Pople puckering coordinates appear to be the natural candidate variables to explore the conformational space of cyclic compounds and in literature different parametrizations have been used to this end. However, while every parametrization is equivalent in identifying conformations, it is not obvious that they can also act as proper collective variables for the exploration of the puckered conformations free energy surface. It is shown that only the polar parametrization is fit to produce an unbiased estimate of the free energy landscape. As an example, the case of a six-membered ring, glucuronic acid, is presented, showing the artifacts that are generated when a wrong parametrization is used.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Termodinámica
/
Ácido Glucurónico
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Chem Phys
Año:
2009
Tipo del documento:
Article
País de afiliación:
Italia