Clopidogrel versus low-dose aspirin as risk factors for epistaxis.
Clin Otolaryngol
; 34(3): 232-5, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19531172
ABSTRACT
OBJECTIVES:
To quantify the relative risk of epistaxis for patients taking low-dose aspirin or clopidogrel compared to patients taking neither drug.DESIGN:
Case-control study.SETTING:
Primary care.PARTICIPANTS:
10,241 patients from three GP practices in the West Midlands. MAIN OUTCOMEMEASURES:
Epistaxis resulting in presentation to the GP, attendance at Accident & Emergency, or referral to ENT outpatients.RESULTS:
There was a significant difference in the proportion of patients with epistaxis across the three groups (chi(2) = 84.1; 2 degrees of freedom; P < 0.000001). Relative risk of epistaxis was increased in both the aspirin (RR = 9.04; 95% CI = 5.13-15.96) and clopidogrel (RR = 6.40; 95% CI = 2.33-17.56) groups compared to the no drug group. There was no increased risk of epistaxis with aspirin compared to clopidogrel (RR = 1.4; 95% CI = 0.6-3.4).CONCLUSION:
There is an increased risk of troublesome epistaxis in patients taking aspirin or clopidogrel. There is no significant difference in risk of epistaxis between the two drug groups.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ticlopidina
/
Inhibidores de Agregación Plaquetaria
/
Aspirina
/
Epistaxis
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Otolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido