Quantitation of human herpesvirus 8 (HHV-8) antibody in patients transfused with HHV-8-seropositive blood.
Transfusion
; 49(10): 2208-13, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19555417
ABSTRACT
BACKGROUND:
Human herpesvirus 8 (HHV-8) is endemic in Uganda where seroprevalence is approximately 40%. In a previous study, Ugandan patients receiving blood transfusions had multiple serum specimens collected for 6 months after transfusion to monitor for HHV-8 infection. It was observed that several HHV-8-seronegative patients were unexpectedly HHV-8 seropositive after blood transfusion. STUDY DESIGN ANDMETHODS:
This study measured HHV-8 antibody in serially collected serum specimens from 542 patients who received transfusions and evaluated the risk of HHV-8 infection as a function of HHV-8 antibody levels in the donors.RESULTS:
HHV-8 antibody was observed in 52% of patients transfused with HHV-8-seropositive blood in amounts that corresponded with their donor's antibody titer and waned within 40 days. Higher levels of passive HHV-8 antibody in patients who received transfusions appeared to be associated with a lower risk of HHV-8 infection.CONCLUSION:
The source of transient antibody in patients who received transfusions was determined to be the transfused blood. Donors with higher HHV-8 antibody titers may have been less likely to have infectious virus in the blood.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Herpesviridae
/
Herpesvirus Humano 8
/
Reacción a la Transfusión
/
Anticuerpos Antivirales
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Transfusion
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos