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Effects of antalarmin and nadolol on the relationship between social stress and pulmonary metastasis development in male OF1 mice.
Vegas, O; Garmendia, L; Arregi, A; Beitia, G; Azpiroz, A.
Afiliación
  • Vegas O; Department of Basic Psychological Processes and their Development, Avda, Tolosa 70, Basque Country University, 20018 San Sebastián, Spain.
Behav Brain Res ; 205(1): 200-6, 2009 Dec 14.
Article en En | MEDLINE | ID: mdl-19573565
ABSTRACT
It has been found that acute social stress in male OF1 mice produced a general immunosuppression and increased B16F10 tumor development. This study examined the effects of blocking either the hypothalamic-pituitary-adrenocortical (HPA) axis or the sympathetic adrenomedullary (SAM) system on the impact of such stress on tumor development. Naive male OF1 mice were individually housed for 12 days before being inoculated with tumor cells or vehicle. Six days later, tumor-bearing mice were inoculated with antalarmin (a corticotropin-releasing factor receptor antagonist), nadolol (a beta-adrenergic antagonist) or vehicle. All these mice were subjected to social stress by pairing them for 24h with counterparts selected for their high and homogeneous levels of aggressiveness. The pairs were only in physical contact for three 5-min periods, being in sensory contact for the rest of this period. One hour after social stress, serum corticosterone and IFN-gamma levels were analyzed in each experimental group. Fifteen days later, lungs were removed to determine the number of metastatic foci with their areas, and blood samples were taken to assess serum titers of corticosterone and IFN-gamma. Both antalarmin and nadolol-treated mice developed significantly fewer metastatic foci with smaller areas than vehicle-treated subjects although only the group treated with antalarmin had reduced corticosterone levels. This study confirms that social stress has complex effects on immune system and tumor development that are not simply linked to corticosterone titers.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Conducta Social / Estrés Psicológico / Nadolol / Fármacos del Sistema Nervioso Central / Neoplasias Pulmonares Aspecto: Determinantes_sociais_saude Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2009 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Conducta Social / Estrés Psicológico / Nadolol / Fármacos del Sistema Nervioso Central / Neoplasias Pulmonares Aspecto: Determinantes_sociais_saude Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2009 Tipo del documento: Article País de afiliación: España