Nanopore with Transverse Nanoelectrodes for Electrical Characterization and Sequencing of DNA.
Sens Actuators B Chem
; 132(2): 593-600, 2008 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-19584949
ABSTRACT
A DNA sequencing device which integrates transverse conducting electrodes for the measurement of electrode currents during DNA translocation through a nanopore has been nanofabricated and characterized. A focused electron beam (FEB) milling technique, capable of creating features on the order of 1 nm in diameter, was used to create the nanopore. The device was characterized electrically using gold nanoparticles as an artificial analyte with both DC and AC measurement methods. Single nanoparticle/electrode interaction events were recorded. A low-noise, high-speed transimpedance current amplifier for the detection of nano to picoampere currents at microsecond time scales was designed, fabricated and tested for future integration with the nanopore device.
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Colección:
01-internacional
Base de datos:
MEDLINE
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En
Revista:
Sens Actuators B Chem
Año:
2008
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Article