Your browser doesn't support javascript.
loading
Interleukin-18: an independent predictor of cardiovascular events in patients with acute coronary syndrome after 6 months of follow-up.
Furtado, Mariana Vargas; Rossini, Ana Paula Webber; Campani, Raquel Barth; Meotti, Carolina; Segatto, Majorie; Vietta, Giovanna; Polanczyk, Carísi Anne.
Afiliación
  • Furtado MV; Graduate Program in Cardiology of Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre RS 90035-903, Brazil. mvargasfurtado@gmail.com
Coron Artery Dis ; 20(5): 327-331, 2009 Aug.
Article en En | MEDLINE | ID: mdl-19593889
BACKGROUND: Interleukin-18 (IL-18), a proinflammatory cytokine, has been associated with atherogenesis and plaque rupture in acute coronary syndrome (ACS). Recent studies suggest that IL-18 may have a long-term prognostic value. The aim of this study was to evaluate the relationship between IL-18 levels and major adverse cardiovascular events within 6 months of follow-up in post-ACS patients. METHODS: One hundred and twelve consecutive patients admitted to a university hospital with ACS were included in the study. IL-18 and C-reactive protein were measured within the first 24 h of admission. Six months after hospital discharge, the incidence of major adverse cardiovascular events (cardiovascular death, new episode of ACS, and need for unplanned revascularization) was assessed. RESULTS: Mean age of patients was 64 +/- 11 years, and 58 (52%) were male. During the 6 months of follow-up, 33 patients (31.4%) experienced major adverse cardiovascular events. Median IL-18 serum levels were higher among patients who had events than among those who did not: 271.7 pg/ml (interquartile range: 172.9-389.6) and 139.7 pg/ml (interquartile range: 99.9-265.7), respectively (P < 0.01). In the Cox multivariate analysis, after adjustment for clinical risk factors and serum troponin, elevated levels of IL-18 were associated with higher incidence of events (hazard ratio: 2.5; 95% confidence interval: 1.14-5.52; P = 0.023). In this population, C-reactive protein was of borderline significance for events. CONCLUSION: Serum IL-18 levels in ACS patients were independent predictors of long-term cardiovascular events. These findings support the association between inflammation and prognosis of ACS patients, as well as the clinical impact of this biomarker.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Mediadores de Inflamación / Interleucina-18 / Síndrome Coronario Agudo Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Coron Artery Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Mediadores de Inflamación / Interleucina-18 / Síndrome Coronario Agudo Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Coron Artery Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2009 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido