Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge.
Eur J Immunol
; 39(8): 2120-5, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19609980
ABSTRACT
Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8(+) effectors. Thus, double deficiency in OX40 and CD30 leads to CD8(+) cell loss during expansion after immunization either with OVA or with murine CMV. Following their contraction, OX40- and CD30-deficient CD8(+) T cells persist normally in CMV-infected mice. In contrast, persistence after OVA challenge is dependent on OX40 and CD30. Collectively, our data define the important role of both OX40 and CD30 during CD8(+) T-cell activation, and show that long-term CD8 persistence after contraction is regulated not only by stimulatory receptors but also by the nature of the antigen or how the antigen is presented.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Antígeno Ki-1
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Linfocitos T CD8-positivos
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Receptores OX40
/
Antígenos
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido