Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation.
Nat Struct Mol Biol
; 16(8): 840-6, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19620966
ABSTRACT
Bacterial small noncoding RNAs (sRNAs) generally recognize target mRNAs in the 5' region to prevent 30S ribosomes from initiating translation. It was thought that the mRNA coding sequence (CDS) was refractory to sRNA-mediated repression, because elongating 70S ribosomes have an efficient RNA helicase activity that prevents stable target pairing. We report that the Hfq-associated MicC sRNA silences Salmonella typhimurium ompD mRNA via a
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biosíntesis de Proteínas
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Sistemas de Lectura Abierta
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Idioma:
En
Revista:
Nat Struct Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2009
Tipo del documento:
Article
País de afiliación:
Alemania