Synthesis of a simplified transition-state analogue in an attempt to obtain an inhibitor of CMP-KDO synthetase.
Acta Chem Scand (Cph)
; 44(10): 1058-61, 1990 Nov.
Article
en En
| MEDLINE
| ID: mdl-1964386
ABSTRACT
The thioglycoside 5 of 3-deoxy-beta-D-manno-2-octulosonic acid (beta-KDO) has been synthesized in an attempt to make a simplified transition-state analogue inhibitor of the enzyme CMP-KDO synthetase (3-deoxy-D-manno-octulosonate cytidylyltransferase). Compound 5 was tested in vitro and was found to have no inhibitory activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azúcares Ácidos
/
Nucleotidiltransferasas
Idioma:
En
Revista:
Acta Chem Scand (Cph)
Año:
1990
Tipo del documento:
Article
País de afiliación:
Suecia