Serum and tissue selenium levels in gastric cancer patients and correlation with CEA.
Anticancer Res
; 29(8): 3465-7, 2009 Aug.
Article
en En
| MEDLINE
| ID: mdl-19661375
ABSTRACT
BACKGROUND:
An inverse relationship between selenium (Se) intake and cancer mortality is evident in humans. MATERIALS ANDMETHODS:
In eighty patients who had been operated on for primary gastric cancer, serum Se and carcinoembryonic antigen (CEA) levels were measured preoperatively using a fluorometric and immunoradiometric assay (IRMA), respectively.RESULTS:
The serum Se levels were 43+/-6.3 microg l(-1) in the patient group and 68.7+/-4.5 microg l(-1) in healthy individuals (p<0.001). The serum CEA was 12+/-1.9 U ml(-1) in the gastric cancer patients and 2.1 U ml(-1) in the control group (p<0.001). The Se tissue concentrations were 2,640+/-220 mg g(-1) in excised neoplastic tissue and 685+/-115 mg g(-1) in non-neoplastic tissue (p<0.001). An inverse correlation between Se and CEA serum levels was found (r=-0.782). There was no correlation between serum/tissue Se concentration and disease stage/histological type or gender in the patient group.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Selenio
/
Neoplasias Gástricas
/
Adenocarcinoma
/
Antígeno Carcinoembrionario
/
Biomarcadores de Tumor
/
Neoplasias Intestinales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
Grecia