Constituents of Tinospora sinensis and their antileishmanial activity against Leishmania donovani.
Nat Prod Res
; 23(12): 1134-43, 2009.
Article
en En
| MEDLINE
| ID: mdl-19662579
ABSTRACT
Two new compounds 4-methyl-heptadec-6-enoic acid ethyl ester (2) and 3-hydroxy-2,9,11-trimethoxy-5,6-dihydro isoquino[3,2-a]isoquinolinylium (7) were isolated from an ethanolic extract of the stems of Tinospora sinensis, along with six known compounds (1, 3-6 and 8). The structures of new compounds were established on the basis of detailed spectroscopic studies. Compound 7 exhibited the highest in vitro antileishmanial activity against Leishmania donovani promastigotes and intracellular amastigotes, whereas compounds 2, 4, 5 and 6 demonstrated moderate activity. Other compounds were found to be inactive.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leishmania donovani
/
Extractos Vegetales
/
Tinospora
/
Antiprotozoarios
Límite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Año:
2009
Tipo del documento:
Article
País de afiliación:
India