Randomized clinical trial of folate supplementation in patients with peripheral arterial disease.
Br J Surg
; 96(9): 990-8, 2009 Sep.
Article
en En
| MEDLINE
| ID: mdl-19672935
ABSTRACT
BACKGROUND:
The aim was to determine whether folate supplementation improved arterial function in patients with peripheral arterial disease (PAD).METHODS:
Individuals with PAD were randomly assigned to receive 400 microg folic acid (45 patients) or 5-methyltetrahydrofolate (5-MTHF) (48) daily, or placebo (40) for 16 weeks. Primary endpoints were changes in plasma total homocysteine (tHcy), ankle brachial pressure index (ABPI) and pulse wave velocity (PWV). Secondary outcomes were changes in plasma inflammatory markers.RESULTS:
Plasma tHcy was significantly reduced in folic acid and 5-MTHF groups compared with controls median difference - 2.12 (95 per cent confidence interval - 3.70 to - 0.75) micromol/l (P = 0.002) and - 2.07 (-3.48 to - 0.54) micromol/l (P = 0.007) respectively. ABPI improved significantly median difference 0.07 (0.04 to 0.11) (P < 0.001) and 0.05 (0.01 to 0.10) (P = 0.009) respectively. Brachial-knee PWV (bk-PWV) decreased significantly in individuals receiving 5-MTHF and tended to be reduced in those taking folic acid compared with controls median difference - 1.10 (-2.20 to - 0.20) m/s (P = 0.011) and - 0.90 (-2.10 to 0.00) m/s (P = 0.051) respectively. Plasma levels of inflammatory markers were not affected.CONCLUSION:
Folate administration reduced plasma homocysteine, and slightly improved ABPI and bk-PWV.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fármacos Cardiovasculares
/
Tetrahidrofolatos
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Ácido Fólico
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Claudicación Intermitente
Tipo de estudio:
Clinical_trials
Límite:
Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Br J Surg
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido