Safety of and compliance with community-based ivermectin therapy.
Lancet
; 335(8702): 1377-80, 1990 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-1971669
In a study of the safety, acceptability, and efficacy of ivermectin for community-based mass treatment of onchocerciasis, the drug was issued twice, one year apart, to the population of a rubber plantation (14,000 people) in Liberia, where over 80% of the adults have Onchocerca volvulus infection. The plantation microfilarial load in a sample of adults was reduced by 86% 6 months after initial treatment and by 78% after 1 year. Compliance was 97% with each round of treatment. After the initial treatment of 7699 people, 101 (1.3%) had moderate adverse reactions. After re-treatment only 37 (0.5%) people had moderate adverse reactions. No ivermectin-related death or severe adverse reactions occurred. The data show that community-based treatment with ivermectin is well accepted and effective in reducing microfilarial loads. Ivermectin is likely to provide the first realistic means of chemotherapy-based control of onchocerciasis on a mass scale.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oncocercosis
/
Ivermectina
Tipo de estudio:
Screening_studies
Límite:
Adolescent
/
Adult
/
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Lancet
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Reino Unido