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The effect of anti-tumor necrosis factor agents on sexual dysfunction in male patients with ankylosing spondylitis: a pilot study.
Oh, J S; Heo, H-M; Kim, Y-G; Lee, S G; Lee, C-K; Yoo, B.
Afiliación
  • Oh JS; Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.
Int J Impot Res ; 21(6): 372-5, 2009.
Article en En | MEDLINE | ID: mdl-19759542
Sexual dysfunction is a common problem among patients with ankylosing spondylitis (AS). This study was an open-label study without placebo to assess sexual dysfunction in male patients with AS, and to determine whether sexual function might improve with the use of tumor necrosis factor (TNF)-alpha blockers. Twenty-two males with AS (age, 29-48 years) were treated for 3 months with TNF-alpha blockers. Before and after treatment, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was measured, and all patients completed the International Index of Erectile Function (IIEF) questionnaire, a self-administered measure of sexual dysfunction with five domains: erectile function (EF), intercourse satisfaction (IS), orgasmic function (OF), sexual desire (SD) and overall satisfaction (OS). There were significant improvements in BASDAI after treatment with TNF-alpha blockers (P<0.001). Anti-TNF-alpha treated patients showed significant improvements in four out of the five IIEF domains (EF, P<0.001; IS, P<0.001; SD, P=0.006; OS, P=0.033). Among patients with erectile dysfunction, there were significant improvements in three IIEF domains (EF, P=0.006; IS, P=0.007; SD, P=0.018). Only IS domain of IIEF showed a significant correlation with BASDAI (partial correlation coefficient = -0.484, P=0.026). This study showed that anti-TNF-alpha therapy may improve sexual dysfunction in male AS patients, in addition to reducing disease activity.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunciones Sexuales Fisiológicas / Espondilitis Anquilosante / Factor de Necrosis Tumoral alfa Tipo de estudio: Clinical_trials / Etiology_studies Aspecto: Patient_preference Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Int J Impot Res Asunto de la revista: MEDICINA REPRODUTIVA / UROLOGIA Año: 2009 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Disfunciones Sexuales Fisiológicas / Espondilitis Anquilosante / Factor de Necrosis Tumoral alfa Tipo de estudio: Clinical_trials / Etiology_studies Aspecto: Patient_preference Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Int J Impot Res Asunto de la revista: MEDICINA REPRODUTIVA / UROLOGIA Año: 2009 Tipo del documento: Article Pais de publicación: Reino Unido