Determination of poly(epsilon-caprolactone) solubility parameters: application to solvent substitution in a microencapsulation process.
Int J Pharm
; 383(1-2): 236-43, 2010 Jan 04.
Article
en En
| MEDLINE
| ID: mdl-19781605
ABSTRACT
The evolution of regulation on chemical substances (i.e. REACH regulation) calls for the progressive substitution of toxic chemicals in formulations when suitable alternatives have been identified. In this context, the method of Hansen solubility parameters was applied to identify an alternative solvent less toxic than methylene chloride used in a microencapsulation process. During the process based on a multiple emulsion (W/O/W) with solvent evaporation/extraction method, the solvent has to dissolve a polymer, poly(epsilon-caprolactone) (PCL), which forms a polymeric matrix encapsulating or entrapping a therapeutic protein as the solvent is extracted. Therefore the three partial solubility parameters of PCL have been determined by a group contribution method, swelling experiments and turbidimetric titration. The results obtained allowed us to find a solvent, anisole, able to solubilize PCL and to form a multiple emulsion with aqueous solutions. A feasibility test was conducted under standard operating conditions and allowed the production of PCL microspheres.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poliésteres
/
Solventes
/
Composición de Medicamentos
Idioma:
En
Revista:
Int J Pharm
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia