Somatostatin inhibition of VIP- and isoproterenol-stimulated cyclic AMP accumulation in dissociated cells from rat cerebral cortex.
Neuropeptides
; 15(4): 235-9, 1990 Apr.
Article
en En
| MEDLINE
| ID: mdl-1979662
ABSTRACT
Freshly dissociated cerebral cortex cells from adult rats have been used in the present study to determine if dual regulation of cyclic AMP levels by inhibitory and stimulatory agents can be expressed in the mature brain. Somatostatin, an inhibitory agent, barely affected the basal cyclic AMP metabolism while vasoactive intestinal peptide (VIP) and isoproterenol, two stimulatory agents enhanced cyclic AMP production. However, this increase was depressed by somatostatin, which decreased the efficiency, but not the potency, of the effects of the two stimulatory agents on cyclic AMP accumulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Somatostatina
/
Péptido Intestinal Vasoactivo
/
Corteza Cerebral
/
AMP Cíclico
/
Isoproterenol
Límite:
Animals
Idioma:
En
Revista:
Neuropeptides
Año:
1990
Tipo del documento:
Article
País de afiliación:
España