G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis.
Nat Rev Rheumatol
; 5(10): 554-9, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19798030
ABSTRACT
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an established role as growth factors in clinical practice. G-CSF and GM-CSF regulate myeloid cell production, differentiation and activation, and might also be important for driving inflammatory responses. Inappropriate engagement of this pathway could be a critical amplification mechanism when maladaptive immune responses predispose to autoimmunity and sterile tissue inflammation. We postulate that antagonism of G-CSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Factor Estimulante de Colonias de Granulocitos
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
/
Antirreumáticos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Rheumatol
Asunto de la revista:
REUMATOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Australia