CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.
Rheumatology (Oxford)
; 48(12): 1502-5, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19815671
ABSTRACT
OBJECTIVE:
To investigate whether single nucleotide polymorphisms (SNPs) within cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with ANCA-associated small vessel vasculitis (SVV).METHODS:
The CTLA-4 CT60 (exon 4), +49 (exon 1) and -318 (promoter region) genotypes were determined by PCR and restriction fragment length polymorphism (RFLP) in 222 white Caucasians of UK origin with SVV and 670 ethnically matched controls.RESULTS:
The CTLA-4 exon 1 (+49) and 4 (CT60) polymorphisms are associated with SVV (+49 chi(2) = 10.965, P = 0.004; CT60 chi(2) = 12.017, P = 0.002). Both disease-susceptible and disease-protective haplotypes have been identified in this cohort, and their frequencies are similar in the subtypes of WG and microscopic polyangiitis.CONCLUSION:
This study provides further evidence that CTLA-4, a susceptibility locus for a number of common autoimmune diseases, may also be involved in the development of ANCA-associated SVV.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos CD
/
Polimorfismo de Nucleótido Simple
/
Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Rheumatology (Oxford)
Asunto de la revista:
REUMATOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido