[Tongxie Yaofang inhibits the contraction of colonic smooth muscle isolated from rats through a mechanism related to calcium mobilization].
Zhong Xi Yi Jie He Xue Bao
; 7(10): 958-62, 2009 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-19828107
ABSTRACT
OBJECTIVE:
To study the relationship between the inhibitory effects of Tongxie Yaofang, a compound traditional Chinese herbal medicine, on the contraction of the colonic smooth muscle isolated from rats and calcium mobilization.METHODS:
By measuring the tension of the isolated colonic smooth muscle strips, the inhibitory effects of Tongxie Yaofang on the contraction induced by acetylcholine (ACh), KCl and exhausting Ca(2+) of internal calcium store were assessed respectively.RESULTS:
Tongxie Yaofang could concentration-dependently inhibit the contraction of isolated rat colonic smooth muscle strips induced by KCl and exhausting the Ca(2+) of internal calcium store. Tongxie Yaofang could also inhibit the tension of the second contractile phase induced by ACh (P<0.01, vs control), but had no influence on the first contractile phase.CONCLUSION:
Tongxie Yaofang can inhibit the contraction of isolated rat colonic smooth muscle strips mainly by preventing the influx of extracellular Ca(2+), which may be associated with blocking voltage-dependent channel, store-operated channel and receptor-operated channel, but not by preventing the release of internal Ca(2+) from calcium store.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Calcio
/
Colon
/
Contracción Muscular
Límite:
Animals
Idioma:
Zh
Revista:
Zhong Xi Yi Jie He Xue Bao
Asunto de la revista:
MEDICINA
/
TERAPIAS COMPLEMENTARES
Año:
2009
Tipo del documento:
Article
País de afiliación:
China