Rhodium-catalyzed synthesis of 3-hydroxy-beta-lactams via oxonium ylide generation: three-component reaction between azetidine-2,3-diones, ethyl diazoacetate, and alcohols.
J Org Chem
; 74(21): 8421-4, 2009 Nov 06.
Article
en En
| MEDLINE
| ID: mdl-19831381
ABSTRACT
3-Substituted-3-hydroxy-beta-lactams, with two new adjacent stereogenic centers, have been prepared in a single step by a rhodium-catalyzed, three-component reaction between azetidine-2,3-diones, ethyl diazoacetate, and alcohols. Good to moderate stereoselectivity was obtained depending on the alcohol used. The stereochemistry of the new centers has been undoubtedly assigned by single crystal X-ray diffraction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rodio
/
Azetidinas
/
Compuestos de Diazonio
/
Alcoholes
/
Lactamas
Idioma:
En
Revista:
J Org Chem
Año:
2009
Tipo del documento:
Article
País de afiliación:
España