The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.
Bioorg Med Chem Lett
; 19(22): 6340-5, 2009 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-19833514
ABSTRACT
For a series of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Relación Estructura-Actividad
/
Inhibidores de la Dipeptidil-Peptidasa IV
/
Amidas
/
Aminobutiratos
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Suiza