Pathology of human-mouse somatic cell hybrid tumors.
J Natl Cancer Inst
; 59(4): 1243-9, 1977 Oct.
Article
en En
| MEDLINE
| ID: mdl-198557
ABSTRACT
Somatic cell hybrids between mouse peritoneal macrophages and simian virus 40-transformed human cells injected sc into nude mice resulted in a formation of tumors with two distinct growth rates and growth patterns 1) rapid growing, irregularly circumscribed, with necrotic foci and prominent vascular channels lined by tumor cells and 2) slow growing, small, well-circumscribed, and nonvascular. Individual tumor cells were ultrastructurally classified as undifferentiated mesenchymal cells indistinguishable within these two tumor types. Characteristics of each tumor type were retained during subsequent passages in nude mice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Híbridas
/
Neoplasias Experimentales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Natl Cancer Inst
Año:
1977
Tipo del documento:
Article