Successful preimplantation genetic diagnosis of Hb Bart's hydrops fetalis in Singapore after fresh and frozen embryo replacement cycles.
Ann Acad Med Singap
; 38(10): 910-3, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19890585
ABSTRACT
INTRODUCTION:
We report the fi rst successful preimplantation genetic diagnosis (PGD) for Hb Bart's hydrops fetalis in Singapore, involving both fresh and frozen embryo replacement cycles. CLINICAL PICTURE Two couples who were carriers of the Southeast Asian type double gene deletion (--(SEA) deletion carriers) requested for PGD. Couple A had 2 previous affected pregnancies, while couple B have a child of unknown genotypic status. TREATMENT One PGD cycle was performed for each couple. The --(SEA) deletion was detected using a gap-PCR strategy. Couple A had 1 fresh-embryo replacement cycle while couple B underwent 2 frozen-embryo replacement cycles.OUTCOME:
Couple A achieved a twin pregnancy. Second trimester complications resulted in premature delivery, where 1 baby girl survived. Couple B achieved a singleton pregnancy resulting in delivery of a healthy baby boy. Genotype analysis of all babies confirmed the PGD results consistent with clinically unaffected status.CONCLUSIONS:
We have successfully performed PGD to avoid Hb Bart's hydrops fetalis syndrome.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hemoglobinas Anormales
/
Hidropesía Fetal
/
Pruebas Genéticas
/
Diagnóstico Preimplantación
/
Transferencia de Embrión
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
Ann Acad Med Singap
Año:
2009
Tipo del documento:
Article
País de afiliación:
Singapur